Carolina Panthers - November 23, 2025

How To Watch: Panthers at 49ers

How to watch, listen and follow: Carolina at San Francisco 49ers in Week 12

The Panthers game will air on ESPN at 8:15 p.m. ET.

Week 12 Uniform Combination, Presented by CEENTA

TOP HEADLINES

NEWS
5 things to watch as Panthers take on 49ers, from Hubbard's impact to slowing down McCaffrey, and more

NEWS
Week 12 Saturday Injury Report: Three ruled out for 49ers game

NEWS
Three takeaways from Saturday, including another new offensive line look

PHOTOS AND MORE!

PHOTOS
PHOTOS | Panthers practice | Week 12 vs San Francisco 49ers

Check out the best shots of Friday's practice as the Panthers' prepare for their Week 12 matchup against the San Francisco 49ers.

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VIDEOS
Dave Canales give game status updates before matchup with 49ers

Watch the Panthers' coach give the Week 12 injury status of players and reflect on the team's improvement this season.

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