ProHealth Longevity - June 9, 2026

The Brain Nutrient You Don't Produce

11-year study links higher levels to cognitive health* ͏ ͏ ͏...

Your brain uses enormous amounts of energy, generating oxidative stress in the process.* In the 2025 Hisayama Study, researchers followed 1,344 adults for over a decade and found that individuals with higher serum ergothioneine levels showed better maintenance of cognitive function over time.*¹

Why this matters:

Notably, this association remained significant even among individuals with high vegetable intake and otherwise healthy dietary patterns, suggesting ergothioneine may offer unique nutritional support beyond diet alone.^*1

Researchers believe ergothioneine may help support the brain’s natural antioxidant defenses and healthy inflammatory balance, both important components of healthy cognitive aging.^*1

†Expires 6/22/26. Not available with other offers, previous purchases, or Subscribe & Save.

Targeted Antioxidant Support for the Aging Brain*

The brain is especially vulnerable to oxidative stress due to its high energy demands.^*

Ergothioneine is actively transported into high-demand tissues like the brain and mitochondria through a specialized transporter known as OCTN1.^*2 Research suggests it is efficiently absorbed, can cross the blood-brain barrier, and is retained in tissues for extended periods.^*2

Within cells, ergothioneine acts as a potent antioxidant that helps scavenge free radicals and support healthy intracellular redox balance — important processes involved in healthy cognitive aging.^*2

Unlike many antioxidants, ergothioneine is highly stable and resistant to auto-oxidation, allowing it to maintain its antioxidant activity under a wide range of physiological conditions.*² Emerging research suggests ergothioneine’s benefits extend beyond brain health alone. Its antioxidant activity has also been studied for its role in healthy cellular aging and telomere maintenance.*3

3,236 Healthy Adults Followed

A 2020 observational study involving 3,236 healthy adults found that higher ergothioneine levels were associated with better cardiovascular health, longer lifespan, and greater healthspan outcomes.^*4

“As a physician researcher, I depend on objective, evidence-based clinical data. Clinical trials involving Ergo provided that.”

“Ergothioneine seems to give me a clarity of mind and better concentration. Happy I found it. It’s a good thing.”

“This is the highest dose I’ve seen on the market. One of the most interesting longevity nutrients I’ve researched. I take it daily.”

Questions? Our Longevity Experts are here to help.

References:
1. Meng X, et al. Psychiatry Clin Neurosci. 2025;79(12):808-816.
2. Tian TT, et al. Food Front. 2026;7:e70207.
3. Samuel P, et al. J Diet Suppl. 2022;19(2):212-225.
4. Smith E, et al. Heart. 2020;106(9):691-697.

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