San Francisco 49ers - December 21, 2025
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Ways to Watch and Listen: 49ers vs. Colts | Week 16 'Monday Night Football'The 49ers will travel to Indianapolis in Week 16 to face the Colts at Lucas Oil Stadium for "Monday Night Football." The matchup is set to kick off at 5:15 p.m. PT on Monday, December 22. Here are all the ways to follow the game.
Kittle, McCaffrey, and White Talk December Football, Playoff PushThe 49ers players discussed the energy inside the locker room, shared the importance of December games, and described the team's mindset as the 49ers continue their push towards the postseason.
Malik Mustapha Finding His Stride as 49ers Enter Pivotal Monday Night MatchupComing off one of his strongest performances of the season in the Week 15 win over the Tennessee Titans, Mustapha recorded 10 tackles while allowing just one catch for two yards when targeted. Opposing quarterbacks posted a 79.2 passer rating throwing his way.
